DLBCL Case Study To reveal the molecular heterogeneity of DLBCL samples which determines patient’s chance of survival.

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The set of 50 genes separate samples into DLBCL-alive, DLBCL-dead and a third group. Number of samples analyzed: DLBCL-alive = 28 DLBCL-dead = 32 Germinal centre B = 3 Activated blood B = 12 Resting/activated T = 6 FL = 9 CLL = 12 Transformed cell lines = 6 NI.lymph node/tonsil = 4 Resting blood B = 6
Examine the three groups, which reveals the molecular heterogeneity of DLBCL, determining the chance of survival The left tree (pink-colored tree) contains mostly DLBCL-alive, FL, NI.lymph node/tonsil samples. The right tree (top red and bottom green tree) contains mostly DLBCL-dead, resting/activated T, transformed cell lines samples. The middle tree (green color top to bottom) contains mostly activated blood B, CLL, resting blood B samples.